Your Genes Are
Not the Whole Story
DNA sets part of the picture.
Gene expression, shaped by daily choices, plays a large role too.
Medical Disclaimer
This content is for informational and educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
"It Runs in My Family"
Is Not the Whole Picture
A Common Belief
- "It runs in my family" means I'm stuck with it
- My genes are my destiny
- DNA is a blueprint written in stone
- If my parents had it, I will too
- Genetic testing tells my fate
A Fuller Picture
- Family history reflects inherited patterns, not a fixed destiny
- Gene expression (epigenetics) plays a large role in health outcomes alongside DNA
- DNA is hardware; gene expression is closer to software
- Gene expression patterns can shift over time
- Gene expression responds to daily choices
Your family history isn't a sentence.
It's a signal worth exploring: a pattern of gene expression that may be able to shift.
4 Metabolites Connected to
Gene Expression
Metabolism produces four key chemical messengers studied in connection with gene expression. When metabolism is sluggish, these metabolites may not be produced in the same amounts.
Acetyl-CoA
A Fuel for Gene Expression
Helps relax chromatin structure, making DNA more accessible for gene expression. Associated with genes involved in energy production and cellular repair.
Alpha-Ketoglutarate
A Regulatory Cofactor
A cofactor for enzymes that remove methyl groups from DNA and histones. Studied in connection with longevity and age-related decline.
NAD+
A Cellular Currency
Involved in energy metabolism and DNA repair. Serves as a substrate for sirtuins, enzymes connected to stress response, inflammation, and longevity pathways.
SAM
The Methyl Donor
The primary methyl donor for DNA and histone methylation. Its synthesis depends on folate, B12, and choline, and it plays a role in gene regulation and mood.
When metabolism is disrupted at step 1, the steps downstream may be affected too.
98.6°F Isn't Just a Number
Many chemical reactions in the body, including the production of methyl groups, are temperature-sensitive.
Enzymes tend to have a narrower optimal temperature range. When body temperature runs low, some processes may slow down.
One Way to Think About It
Lower body temperature may relate to a slower metabolism, which may relate to lower methyl group production, which may relate to changes in gene expression regulation.
Some clients start here
A commonly cited reference point
The Bioenergetic Food Chart
Specific foods, serving sizes, and frequencies discussed in the guide
Methyl Donors
Glycine Sources
Polyphenol Foods
Glucose Sources
Preparation Matters:
- Cook vegetables to increase polyphenol bioavailability
- Choose whole milk over skim for fat-soluble vitamins
- Use sea salt to taste, discussed for thyroid support
- Carbohydrates are part of the plan, not the enemy
Your 7-Day
Epigenetic Reset
A practical introduction to metabolic nutrition. Four simple rules to start with.
Hydrate
Drink at least half your body weight in ounces of water daily
Nourish
Focus on whole, unprocessed foods: vegetables, quality proteins, and healthy fats
Stabilize
Eat meals with a balance of macronutrients to help steady blood sugar
Avoid
Minimize processed sugar, refined grains, and alcohol
These guidelines are aimed at steadier blood sugar, less inflammation, and the methyl donors involved in DNA methylation.
Many people notice a difference by day 7, though individual pace varies.
What's Inside Your
Epigenetic Reset Guide
DNA and Gene Expression
Why family history is not the whole story, and how gene expression plays a large role in health outcomes
The 4 Metabolites
Acetyl-CoA, alpha-KG, NAD+, and SAM: the chemical messengers connected to gene expression
Temperature Connection
Why 98.6°F is a useful marker, and how metabolism relates to gene expression
Bioenergetic Food Chart
Specific foods, serving sizes, and frequencies discussed in the guide
7-Day Reset Protocol
A practical introduction to metabolic nutrition with simple guidelines
Family Health Patterns
How lifestyle choices may help shift long-standing family health patterns
Your Family History
Is a Signal Worth Exploring
"It runs in my family."
Many people say this with a sense of inevitability. Epigenetics research suggests a more nuanced picture.
Inherited sequence
(fixed)
Environment & lifestyle
(changeable)
Can shift
(reversible in many cases)
Lifestyle choices may help influence long-standing family patterns.
It's worth exploring what's within your influence.
Meet Dr. Steven Presciutti, MD
"I kept seeing patients who were told their symptoms were 'just genetic.' When we worked on their metabolic fuel and cellular energy production alongside their care, many saw real changes. I've seen this both in my research background and in clinical practice."
BOARD-CERTIFIED PHYSICIAN
Client Stories
Individual accounts, not representative outcomes. Results vary.
"I was told my thyroid issues were genetic and that I'd need medication indefinitely. After focusing on metabolic health for about 12 weeks, my labs changed. I still work with my doctor on monitoring it."
"My doctor said high cholesterol "ran in my family." Working on metabolic health alongside my doctor's guidance made a real difference for me."
"At 96.4°F, I could barely get through the day. My temperature and energy have both improved since working on this with my care team."
Frequently Asked Questions
Your Genes Are
Part of the Story
Daily choices may send signals that relate to gene expression over time. You have more influence than "it's genetic" suggests.
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Epigenetic Guide
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Energy Essentials
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5-day energy overview
A metabolic approach to exhaustion, led by Dr. Steven Presciutti
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